What is the dosing schedule for the recombinant zoster vaccine (RZV)?

The recombinant zoster vaccine (RZV), commonly referred to as Shingrix, is specifically designed to protect against shingles and is recommended for adults aged 50 years and older. The correct dosing schedule for RZV involves administering two doses, with the first dose given at time zero (month 0) and the second dose administered two months later, at month 2.

This interval between doses is essential for achieving optimal immune response and prolonged protection against the varicella-zoster virus, which causes shingles. The vaccination regimen is structured this way based on clinical trials that demonstrated the effectiveness of this schedule in evoking a strong immune response.

Other schedules would not provide the intended immunity against shingles; for example, one dose at any time or a single annual dose would not provide sufficient protection. Similarly, any schedule suggesting three doses would also be incorrect, as the two-dose protocol is specifically endorsed based on the latest clinical guidelines and trials.